Table 3. Increment sensitivity of SLN analysis for breast cancer metastases.
Frequency of positive SLN | Percentage of positive SLN (%) | P-value * | |
---|---|---|---|
H&E | 6 | 20 | |
IHC | 8 | 26.7 | <0.01 |
NY-BR-1 | 13 | 43.3 | <0.01 |
CK-19 | 8 | 26.7 | <0.01 |
MGB-2 | 11 | 36.7 | <0.01 |
3 markers | 7 | 23.3 | <0.01 |
2 markers | 10 | 33.3 | <0.01 |
1 marker | 15 | 50.0 | <0.01 |
Fisher's exact test two-tailed P-value (compared to H&E alone).
SLN=sentinel lymph node; H&E=haematoxylin and eosin stain; IHC=immunohistochemistry stain for cytokeratin.