Table 3. Uni- and multivariate Cox's proportional hazards analyses of MMP-2, determined by ELISA and BIA, and clinicopathological parameters in relation to the overall tumour-related survival of 81 patients with gastric cancer.

		Univariate			Multivariate
Parameter	n	HR	CI 95%	P	HR	CI 95%	P
Gender
Male vs female	60/21	1.384	0.768–2.494	NS	1.767	0.935–3.342	NS
Age
Median (66 years)	40/41	1.313	0.764–2.255	NS	1.467	0.775–2.774	NS
TNM
I	23/81	1	—		1	—
II	26/81	3.133	1.360–7.222	0.007	4.001	1.510–10.60	0.005
III	25/81	3.021	1.305–6.991	0.010	3.557	1.290–9.813	0.014
IV	7/81	7.387	2.495–21.86	0.000	20.416	4.992–83.49	0.000
Laurén
Diffuse/mixed vs intestinal	30/50	0.889	0.516–1.531	NS	1.152	0.353–3.756	NS
WHO differentiation
Well vs poor	54/26	1.133	0.650–1.975	NS	1.270	0.370–4.363	NS
Borrmann
I+II vs III+IV	55/24	1.118	0.609–2.053	NS	0.761	0.386–1.502	NS
Localisation
Cardia vs rest	36/45	0.573	0.330–0.993	0.034	0.330	0.159–0.682	0.003
Diameter tumour
<5 vs >5 cm	47/34	1.048	0.608–1.808	NS	0.622	0.337–1.149	NS
Eosinophils
Few vs many	56/24	1.035	0.568–1.886	NS	1.743	0.806–3.766	NS
Intestinal metaplasia
Absent vs present	39/42	0.490	0.280–0.858	0.013	0.706	0.379–1.315	NS
Carcinoma
MMP-2 ELISA
<13.4 vs >13.4 ng mg−1 protein	45/31	2.611	1.455–4.686	0.001	2.620	1.249–5.494	0.011
MMP-2 BIA
<80 vs >80 U mg−1 protein	49/23	1.974	1.089–3.577	0.025	1.493	0.655–3.404	NS

HR=hazard ratio; CI=confidence interval.