Table 2. Changes in tumour Ki67 scores with treatment.

	No. of patients
	Changes at 10–14 days				Changes at 3 months
	Increase	No change	Decrease		Increase	No change	Decrease
			by 40%	to <1%			by 40%	<1%
Clinical responders (48)	1	6	41	(8)	0	7	41	(23)
Clinical non-responders (15)	1	3	11	(3)	1	2	12	(4)
Total	2	9	52	(11)	1	9	53	(27)
			P=0.49				P=0.20
Pathology responders (47)	1	4	42	(9)	0	6	41	(23)
Pathology non-responders (15)	1	5	9	(2)	1	3	11	(3)
Total	2	9	51	(11)	1	9	52	(26)
			P=0.034				P=0.15

Statistical comparison of increase (>40%), decrease (>40%) or no change (<40%) compared with pretreatment values by 3 × 2 chi-square testing.