Table 3. Proliferation (Ki67) and progesterone receptor (PgR) expression in samples of human breast epithelium 14 days after being implanted into the athymic nude mice and before the initiation of treatment.
| Population risk | High risk | BRCA1 + BRCA2 | BRCA1 only | ||
|---|---|---|---|---|---|
| Ki67 (%) | |||||
| Median | 1.08 | 1.16 | 1.21 | 1.25 | nsda |
| IQ rangeb | 0.3–2.45 | 0.50–2.30 | 0.57–3.28 | 0.61–2.84 | |
| nc | 110 | 169 | 102 | 66 | |
| PgR (%) | |||||
| Median | 9.60 | 9.12 | 2.94 | 1.99 | P<0.001a |
| IQ range | 5.34–18.48 | 4.32–15.30 | 0.96–8.51 | 0.90–5.04 | |
| n | 63 | 101 | 86 | 52 |
The figures represent positively stained epithelial cells expressed as a percentage of the total number of cells counted.
a
Significance of comparison between risk groups by Kruskal–Wallis test; nsd=no significant difference.
b
IQ range=inter-quartile range.
c
n=number of tissue samples in which parameter could be measured.