Table 4. Tumour mean marker values for pre- and on-treatment performed by quantitative immunofluorescence (unit of measurement is the proportion of area in the epithelium positively stained for each individual marker).
| Pretreatment median (range) | On-treatment median (range) | On- and pre-treat. median (range) difference | Simple P-value | |
|---|---|---|---|---|
| pEGFR | 200 (62, 515) | 123 (−41, 197) | 125 (1, 318) | 0.008 |
| EGFR | 159 (−10, 349) | 200 (125, 552) | −122 (−303, 215) | 0.31 |
| pERK | 280 (189, 590) | 121 (−25, 512) | 181 (35, 266) | 0.008 |
| ERK | 415 (327, 765) | 559 (172, 918) | −38 (−325, 277) | 0.46 |
| p27 | 927 (414, 1614) | 771 (472, 1519) | −33 (−401, 631) | 0.95 |
| Ki-67/MIB-1 | 0.41 (0.26, 0.52) | 0.31 (0.11, 0.46) | 0.13 (−0.09, 0.26) | 0.11 |
| PKB/Akt | 943 (566, 1215) | 918 (694, 1118) | 60 (−343, 364) | 0.64 |
ERK=phospho-extracellular signal-regulated kinase; pEGFR=phospho-epidermal growth factor receptor tyrosine.