Table 2. Characteristics of patients with and without MYCN amplification detected by mass screening for neuroblastoma.
|
Number of cases (%)
|
||||||
|---|---|---|---|---|---|---|
| MNA (>10) | MNA (3–9) | MNA (−) | ||||
| Patient characteristics | (n=13) | (n=20) | (n=1500) | P-value | MNA (+, >3) 3-yr EFS | P-value |
| Tumour stage | ||||||
| I | 0 (0) | 5 (25) | 595 (40) | P<0.001a, P=0.05b | 100 | P=0.021 |
| II | 2 (15) | 5 (25) | 463 (31) | (1,2,4s/3,4) | 86 | (1,2,4s/3,4) |
| III | 2 (15) | 5 (25) | 280 (19) | 71 | ||
| IV | 7 (54) | 2 (10) | 65 (4) | 44 | ||
| IVs | 2 (15) | 3 (15) | 97 (6) | 100 | ||
| Gender | ||||||
| Female | 3 (23) | 11 (55) | 722 (49) | P=0.043a, P=0.579b | 86 | |
| Male | 11 (77) | 9 (45) | 764 (51) | 68 | ||
| Primary site | ||||||
| Adrenal gland | 12 (92) | 13 (65) | 764 (51) | P=0.002a, P=0.131b | 68 | P=0.021 |
| Other abdominal | 0 (0) | 3 (15) | 456 (30) | (adrenal gland/other site) | 100 | (adrenal gland/other site) |
| Chest | 1 (8) | 3 (15) | 224 (15) | 100 | ||
| Pelvis | 0 (0) | 1 (5) | 50 (3) | 100 | ||
| Neck | 0 (0) | 0 (0) | 6 (0) | |||
| VMA | ||||||
| <20 μg mgCr−1 | 3 (23) | 4 (20) | 293 (20) | 100 | ||
| 21–100 μg mgCr−1 | 7 (54) | 15 (75) | 982 (67) | 82 | ||
| >101 μg mgCr−1 | 2 (15) | 1 (5) | 184 (13) | 75 | ||
| (mean: 74.6 μg mgCr−1) | (mean: 54.8 μg mgCr−1) | (mean: 54.4 μg mgCr−1) | P=0.985a, P=0.977b | P=0.364 | ||
| HVA | ||||||
| <20 μg mgCr−1 | 0 (0) | 2 (10) | 206 (14) | 100 | ||
| 21–100 μg mgCr−1 | 7 (54) | 16 (80) | 1084 (74) | 78 | ||
| >101 ng mgCr−1 | 6 (46) | 2 (10) | 170 (12) | 63 | ||
| (mean: 107.1 μg mgCr−1) | (mean: 66.0 μg mgCr−1) | (mean: 55.6 μg mgCr−1) | P=0.008a, P=0.371b | P=0.478 | ||
| NSE | ||||||
| <15 ng ml−1 | 5 (38) | 9 (45) | 526 (47) | 93 | ||
| 16–100 ng ml−1 | 2 (15) | 7 (35) | 568 (51) | 89 | ||
| >101 ng ml−1 | 6 (46) | 2 (10) | 14 (1) | 25 | ||
| (mean: 266.9 ng ml−1) | (mean: 32.6 ng ml−1) | (mean: 26.2 ng m−1l) | P=0.049a, P=0.285b | P=0.0005 | ||
| Ferritin | ||||||
| <30 ng ml−1 | 2 (15) | 5 (25) | 506 (54) | 100 | ||
| 31–100 ng ml−1 | 5 (38) | 8 (40) | 383 (41) | 69 | ||
| >101 ng ml−1 | 6 (46) | 1 (5) | 54 (6) | 43 | ||
| (mean: 167.3 ng ml−1) | (mean: 55.9 ng ml−1) | (mean: 33.7 ng ml−1) | P=0.025a, P=0.032b | P=0.174 | ||
a
P-value between MNA (>10) and MNA (−).
b
P-value between MNA (3–9) and MNA (−).