Table 1. Gene expression profile using Affymetrix arrays of genes differentially expressed in MET1 and MET4 vs PM1cell line and MET1 vs MET4.
| MET1 vs PM1 | MET4 vs PM1 | MET1 vs MET4 | |||
|---|---|---|---|---|---|
| Genbank | Common | Function | Fold +/− | Fold +/− | Fold +/− |
| Ubiquitin cycle/proteolysis and peptidolysis | |||||
| AA020826 | CTSB | Cathepsin B | −5 | ||
| Transport | |||||
| N74607 | AQP3 | Aquaporin 3 | −10 | −6 | |
| AF201942 | NXT2 | Nuclear transport factor 2-like export factor 2 | 8 | ||
| Transcription/replication | |||||
| NM_004364 | CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | −10 | ||
| H94842 | HOXA11 | Homeo box A11 | 6 | 8 | |
| BC005342 | NSBP1 | Nucleosomal-binding protein 1 | 16 | ||
| NM_016594 | FKBP11 | FK506-binding protein 11, 19 kDa | 5 | ||
| AB046692 | AOX1 | Aldehyde oxidase 1 | 8 | ||
| Signalling | |||||
| NM_006176 | NRGN | Neurogranin (protein kinase C substrate, RC3) | 11 | ||
| NM_001945 | DTR | Diphtheria toxin receptor) | 16 | 22 | |
| AA464753 | PDAP1 | Homo sapiens, clone IMAGE:3457786 | −8 | ||
| M14333 | FYN | FYN oncogene related to SRC, FGR, YES | 5 | ||
| NM_004335 | BST2 | Bone marrow stromal cell antigen 2 | 16 | ||
| NM_013447 | EMR2 | egf-like, hormone receptor-like sequence 2 | −6 | ||
| NM_003020 | SGNE1 | Secretory granule, neuroendocrine protein 1 | |||
| (7B2 protein) | 5 | ||||
| AI439556 | TXNIP | Thioredoxin interacting protein | −5 | ||
| Development | |||||
| NM_000366 | TPM1 | Tropomyosin 1 (alpha) | 6 | ||
| NM_003412 | ZIC1 | Zic family member 1 (odd-paired homolog, Drosophila) | 33 | 39 | |
| U61276 | JAG1 | Jagged 1 (Alagille syndrome) | 5 | ||
| NM_014556 | EVC | Ellis van Creveld syndrome | 10 | ||
| Growth factor/chemokine/cytokine/inflammation/immune response | |||||
| NM_002658 | PLAU | Plasminogen activator, urokinase | 6 | ||
| AL573058 | C1R | Complement component 1, r subcomponent | 13 | 10 | |
| M92934 | CTGF | Connective tissue growth factor | 13 | ||
| NM_003596 | TPST1 | Tyrosylprotein sulfotransferase 1 | 8 | ||
| NM_013314 | BLNK | B-cell linker | 6 | ||
| NM_002964 | S100A8 | S100 calcium-binding protein A8 (calgranulin A) | 5 | ||
| NM_002852 | PTX3 | Pentaxin-related gene, rapidly induced by IL-1 beta | 8 | ||
| M69176 | CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 | 6 | ||
| NM_006379 | SEMA3C | Semaphorin 3C | 10 | ||
| NM_002053 | GBP1 | Guanylate-binding protein 1, interferon-inducible, 67 kDa | 7 | ||
| NM_014391 | ANKRD1 | Cardiac ankyrin repeat protein | −8 | ||
| NM_000963 | PTGS2 | Prostaglandin-endoperoxide synthase 2 | 5 | 16 | |
| L27624 | TFPI2 | Tissue factor pathway inhibitor 2 | 9 | ||
| BG166705 | CXCL5 | Chemokine (C-X-C motif) ligand 5 | 227 | ||
| Cell cycle/oncogene/tumour suppressor | |||||
| NM_001759 | CCND2 | Cyclin D2 | −7 | 8 | |
| M15329 | IL1A | Interleukin 1, alpha | 5 | ||
| NM_005504 | BCAT1 | Branched chain aminotransferase 1, cytosolic | 11 | ||
| NM_000393 | COL5A2 | Collagen, type V, alpha 2 | 44 | 23 | |
| NM_000584 | IL8 | Interleukin 8 | 112 | 32 | |
| Metabolism/stress response | |||||
| NM_005965 | MYLK | Myosin, light polypeptide kinase | −7 | 7 | |
| NM_016816 | OAS1 | 2′,5′-oligoadenylate synthetase 1, 40/46 kDa | 5 | ||
| AW614435 | UROD | Uroporphyrinogen decarboxylase | 16 | ||
| AV704962 | SC4MOL | Sterol-C4-methyl oxidase-like | 7 | ||
| NM_004265 | FADS2 | Fatty acid desaturase 2 | 4 | 5 | |
| NM_018192 | LEPREL1 | Leprecan-like 1 | 10 | 15 | |
| NM_007034 | DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 5 | ||
| AF054841 | TM4SF7 | Transmembrane 4 superfamily member 7 | −5 | −6 | |
| NM_000050 | ASS | Argininosuccinate synthetase | −5 | ||
| Cytoskeleton/cell adhesion | |||||
| NM_002628 | PFN2 | Profilin 2 | 25 | 15 | |
| U76549 | KRT8 | Keratin 8 | −6 | ||
| AI831452 | KRT6B | Keratin 6B | 5 | ||
| NM_004791 | ITGBL1 | Integrin, beta-like 1 (with EGF-like repeat domains) | 7 | 15 | |
| AI806793 | COL8A2 | Collagen, type VIII, alpha 2 | 8 | ||
| AI922599 | VIM | Vimentin | 5 | ||
| NM_000422 | KRT17 | Keratin 17 | −5 | ||
| Apoptosis | |||||
| NM_006290 | TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 | 7 | ||
| BG260394 | SNCA | Synuclein, alpha | 8 | 5 | |
| Receptor | |||||
| NM_021913 | AXL | AXL receptor tyrosine kinase | 12 | ||
| NM_000142 | FGFR3 | Fibroblast growth factor receptor 3 | −35 | ||
| Others | |||||
| NM_000104 | CYP1B1 | Cytochrome P450, subfamily I | −7 | ||
| NM_003118 | SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | −7 | ||
| NM_007150 | ZNF185 | Zinc finger protein 185 (LIM domain) | 5 | ||
| BF213279 | FARP1 | FERM, RhoGEF (ARHGEF) pleckstrin domain protein 1 | −8 | ||
| NM_014903 | NAV3 | Neuron navigator 3 | 21 | 18 | |
| M58026 | CALML3 | Calmodulin-like 3 | −11 | ||
| BF217861 | MT1E | Metallothionein 1E | 15 | 23 | |
| NM_020672 | S100A14 | S100 calcium-binding protein A14 | −7 | −12 | |
| NM_024593 | FLJ11767 | Hypothetical protein FLJ11767 | −6 | ||
| NM_000396 | CTSK | Cathepsin K (pycnodysostosis) | 10 | 7 | |
| NM_016081 | KIAA0992 | Palladin | 6 | ||
| NM_005785 | RNF41 | Hypothetical SBBI03 protein | 6 | ||
| NM_004900 | APOBEC3B | Apolipoprotein B | 8 | 7 | |
| AF088867 | AGR2 | Anterior gradient 2 homolog (Xenepus laevis) | 32 | 88 | |
| AF010316 | PTGES | Prostaglandin E synthase | −7 | −6 | |
| NM_002281 | KRTHB1 | Keratin, hair, basic, 1 | −17 | ||
| U10691 | MAGEA3 | Melanoma antigen, family A, 6 | −11 | ||
| AU145365 | — | Clone HEMBA1004629, mRNA sequence | 7 | ||
| AK025430 | — | Hypothetical protein FLJ21777 | −5 | ||
| NM_024554 | PGBD5 | Piggybac transposable element derived 5 | −31 | ||
| NM_018436 | ALLC | Allantoicase | 5 | ||
| NM_025143 | C21orf96 | Hypothetical protein FLJ20856 | 5 | ||
| W72694 | LOC51063 | Hypothetical protein LOC51063 | −8 | ||
Only genes whose expression changed by five-fold or more and P-value of 0.001 or less are listed.