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. 2006 May 16;94(11):1672–1677. doi: 10.1038/sj.bjc.6603155

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Copyright © 2006 Cancer Research UK

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Similar expression pattern of securin (hPTTG1) and 12 established β-catenin/TCF target genes in tumour vs mucosa tissue revealed by hierarchical clustering of microarray data (A). All 13 genes are significantly upregulated in colorectal tumour tissue (T.1–T.6) compared to corresponding normal mucosa (N.1–N.6). Gene expression data are displayed as a heatplot with high expression encoded in red and low gene expression shown in green relative to the mean expression (black). Columns represent tissue samples with the corresponding expression level of the individual genes located in rows. Overexpression of securin in colorectal carcinoma (T) compared to mucosa (N) of seven different cases analysed by real-time RT–PCR (B). Securin-specific mRNA expression in seven tumour tissues relative to corresponding normal mucosa was determined following normalisation to the matching expression values of the housekeeping gene β-actin.