Table 2. Worst grade of toxicity for the 41 patients.
|
Grade
|
||||||||
|---|---|---|---|---|---|---|---|---|
|
1
|
2
|
3
|
4
|
|||||
| Toxicity | Patients | % | Patients | % | Patients | % | Patients | % |
| Anaemia | 7 | 17 | 4 | 10 | 1 | 2 | 0 | |
| Thrombocytopenia | 2 | 5 | 0 | 0 | 0 | |||
| Neutropenia | 12 | 29 | 4 | 10 | 6 | 15 | 14 | 34 |
| Nausea | 8 | 20 | 4 | 10 | 0 | 0 | ||
| Vomiting | 5 | 12 | 2 | 5 | 0 | 0 | ||
| Stomatitis | 2 | 5 | 2 | 5 | 0 | 0 | ||
| Diarrhoea | 9 | 22 | 5 | 12 | 4 | 10 | 0 | |
| Mucositis | 7 | 17 | 2 | 5 | 0 | 0 | ||
| Pain | 1 | 2 | 0 | 0 | 0 | |||
| Fever | 2 | 5 | 5 | 12 | 0 | 0 | ||
| Hypersensitivitya | 0 | 0 | 3 | 7 | 0 | |||
| Neuropathy | 6 | 15 | 1 | 2 | 0 | 0 | ||
| Acne-like rash | 4 | 10 | 3 | 7 | 2 | 5 | 0 | |
| Asthenia | 6 | 15 | 4 | 10 | 2 | 5 | 0 | |
| Increase in transaminases | 6 | 15 | 3 | 7 | 2 | 5 | 0 | |
a
Hypersensitivity reactions after few minutes of starting the first intravenous injection of docetaxel were observed in three patients, which, therefore, were never treated with gefitinib and which were switched to a chemotherapy regimen without docetaxel. Toxicities were recorded according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 2.0.