Table 2. Worst grade of toxicity for the 41 patients.
Grade
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---|---|---|---|---|---|---|---|---|
1
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2
|
3
|
4
|
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Toxicity | Patients | % | Patients | % | Patients | % | Patients | % |
Anaemia | 7 | 17 | 4 | 10 | 1 | 2 | 0 | |
Thrombocytopenia | 2 | 5 | 0 | 0 | 0 | |||
Neutropenia | 12 | 29 | 4 | 10 | 6 | 15 | 14 | 34 |
Nausea | 8 | 20 | 4 | 10 | 0 | 0 | ||
Vomiting | 5 | 12 | 2 | 5 | 0 | 0 | ||
Stomatitis | 2 | 5 | 2 | 5 | 0 | 0 | ||
Diarrhoea | 9 | 22 | 5 | 12 | 4 | 10 | 0 | |
Mucositis | 7 | 17 | 2 | 5 | 0 | 0 | ||
Pain | 1 | 2 | 0 | 0 | 0 | |||
Fever | 2 | 5 | 5 | 12 | 0 | 0 | ||
Hypersensitivitya | 0 | 0 | 3 | 7 | 0 | |||
Neuropathy | 6 | 15 | 1 | 2 | 0 | 0 | ||
Acne-like rash | 4 | 10 | 3 | 7 | 2 | 5 | 0 | |
Asthenia | 6 | 15 | 4 | 10 | 2 | 5 | 0 | |
Increase in transaminases | 6 | 15 | 3 | 7 | 2 | 5 | 0 |
Hypersensitivity reactions after few minutes of starting the first intravenous injection of docetaxel were observed in three patients, which, therefore, were never treated with gefitinib and which were switched to a chemotherapy regimen without docetaxel. Toxicities were recorded according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 2.0.