Table 2. CK18 serum levels during chemotherapy.
|
CK18-Asp396
|
CK18
|
|||
|---|---|---|---|---|
| Day | (U l−1) | % Δa | (U l−1) | % Δ |
| EMP (n=751 cycles) | ||||
| 1 | 102 (59–163)b | 0 | 280 (169–457) | 0 |
| 3 | 101 (63–158) | −1.0 | 303 (184–455) | 8.2 |
| Docetaxel (n=289 cycles) | ||||
| 5 | 123 (86–171) | 0 | 337 (227–514) | 0 |
| 7 | 146 (101–229) | 18.7 | 409 (263–595) | 21.4 |
| (P=0.015) | (P=0.014) | |||
| Vinorelbine (n=462 cycles) | ||||
| 5 | 83 (53–135) | 0 | 255 (165–419) | 0 |
| 7 | 89 (58–159) | 7.2 | 272 (166–451) | 6.7 |
a
Percent change: from day 1 to day 3 and from day 5 to day 7.
b
Median (25th–75th percentile).
CK18=Cytokeratin 18; EMP=estramustine phosphate.