Table 2. Toxicity by dose levels.

	NCI-CTC grade
	Dose levels 1–4			Dose level 5			Dose level 6
	(n=12)			(n=6)			(n=2)
Toxicity	Grade 1/2	Grade 3	Grade 4	Grade 1/2	Grade 3	Grade 4	Grade 1/2	Grade 3	Grade 4
Haematologic
Neutropenia	2	1			2	1		2
Febrile neutropenia				1
Thrombocytopenia	1			1			1
Gastrointestinal
Nausea/vomiting	7			2
Colitis				2				1
Diarrhoea	1			3	1		1
Stomatitis	1			1
Proctitis	1			1
Genitourinary
Cystitis				1
Skin, local toxicity	1
Fatigue/asthenia							1
Fever	1

NCI-CTC=National Cancer Institute Common Toxicity Criteria.

Note: Most severe toxicity of each type experienced by each patient.