Table 3. Worst toxicities by patients reported in the phase II study.

	NCI-CTC grade
	Grade 1	Grade 2	Grade 3	Grade 4
Toxicity	no. (%)	no. (%)	no. (%)	no. (%)
Haematologic
Neutropenia	4 (13)	1 (3)	5 (16)	5 (16)
Febrile neutropenia	1 (3)	2 (6)		2 (6)
Thrombocytopenia	2 (6)	3 (10)
Gastrointestinal
Nausea/vomiting	11 (35)	4 (13)
Colitis	1 (3)	2 (6)
Diarrhoea	2 (6)	5 (16)	6 (19)
Stomatitis			1 (3)
Proctitis	3 (10)	2 (6)
Skin, local toxicity	1 (3)	2 (6)
Fatigue/asthenia	3 (10)	1 (3)
Fever	1 (3)	2 (6)
Paresthesia/dysesthesia	5 (16)

NCI-CTC=National Cancer Institute Common Toxicity Criteria.