Table 3. FGFR4 Arg388 genotype and clinical/pathological variables.
| FGFR4 allele | G/G (%) | G/R (%) | R/R (%) | P-value |
|---|---|---|---|---|
| Patients n=185 | n=101 | n=69 | n=15 | |
| Median age (years) | 68 | 64 | 55 | |
| Age at diagnosis | ||||
| ⩽55 | 28 (28) | 19 (28) | 8 (53) | NS |
| >55 | 73 (72) | 50 (72) | 7 (47) | |
| Sex | ||||
| Male | 53 (29) | 33 (18) | 12 (6) | NS |
| Female | 48 (26) | 36 (19) | 3 (2) | |
| Localisation of tumour | ||||
| Extremities | 64 (35) | 49 (26) | 5 (3) | NS |
| Trunk, head/neck | 37 (20) | 20 (11) | 10 (5) | |
| Microvessel density (n=139) | ||||
| Low | 45 (32) | 33 (24) | 7 (5) | NS |
| Medium | 15 (11) | 12 (9) | 4 (3) | |
| High | 12 (9) | 10 (7) | 1 (1) | |
| CD-31 (meana; n=17) | 38 | 30 | 26 | |
| Ki-67 (meanb; n=17) | 18 | 14 | 41 | |
| pTNM UICC staging (n=185) | ||||
| Ia | 32 (16) | 19 (10) | 3 (2) | NS |
| Ib | 11 (6) | 5 (3) | 2 (1) | |
| IIa | 13 (7) | 17 (9) | 3 (2) | |
| IIb | 6 (3) | 4 (2) | 0 (0) | |
| IIIa | 14 (7) | 11 (6) | 2 (1) | |
| IIIb | 4 (2) | 6 (3) | 1 (1) | |
| IV | 21 (11) | 7 (4) | 4 (2) | |
| pTNM AJCC staging (n=139) | ||||
| Ia | 21 (15) | 15 (11) | 3 (2) | NS |
| Ib | 13 (9) | 4 (3) | 1 (1) | |
| IIa | 4 (3) | 7 (5) | 1 (1) | |
| IIb | 6 (4) | 5 (4) | 2 (1) | |
| IIc | 2 (1) | 3 (2) | 0 (0) | |
| IIIa | 4 (3) | 5 (4) | 2 (1) | |
| IIIb | 10 (7) | 7 (5) | 1 (1) | |
| IIIc | 0 (0) | 3 (2) | 0 (0) | |
| IV | 14 (10) | 4 (3) | 2 (1) | |
| Tumour thickness Breslow | ||||
| ⩽1 mm | 50 (27) | 26 (14) | 4 (2) | 0.02 |
| >1 mm | 51 (28) | 43 (23) | 11 (6) | |
| Clark level | ||||
| I | 0 (0) | 0 (0) | 0 (0) | NS |
| II | 24 (12) | 17 (9) | 2 (1) | (0.004 when |
| III | 39 (20) | 10 (5) | 6 (3) | levels IV+V |
| IV | 37 (19) | 36 (18) | 5 (3) | compared to |
| V | 1 (1) | 6 (3) | 2 (1) | II+III) |
| Ulceration (n=139) | ||||
| Yes | 23 (17) | 19 (14) | 3 (2) | NS |
| No | 51 (37) | 34 (24) | 9 (6) | |
| No. of primary tumours | ||||
| 1 | 75 (41) | 55 (30) | 14 (7) | NS |
| >1 | 26 (14) | 14 (7) | 1 (1) | |
| Metastasis | ||||
| Yes | 39 (21) | 24 (13) | 7 (4) | NS |
| No | 62 (34) | 45 (24) | 8 (4) | |
| No. of metastases | ||||
| 1 | 19 (27) | 7 (10) | 3 (4) | NS |
| >1 | 20 (29) | 17 (24) | 4 (6) | |
| Type of metastasis | ||||
| Local | 14 (36) | 11 (46) | 2 (29) | NS |
| Regional | 4 (10) | 6 (25) | 1 (14) | |
| Distant | 21 (54) | 7 (29) | 4 (57) | |
| Tumour type | ||||
| SSM | 56 (30) | 26 (14) | 5 (3) | 0.002 |
| NMM | 27 (15) | 32 (17) | 9 (5) | |
| Others | 18 (10) | 11 (6) | 1 (1) | |
AJCC, American Joint Committee on Cancer; NMM, nodular malignant melanoma; No., number; NS, not significant; pTNM, tumour, lymph node and distant metastasis status; SSM, superficial spreading melanoma; UICC, Union Internationale Contre le Cancer; .
a
Vessels per visual field.
b
Cells per visual field.