Table 2. SNPs genotyped in the study set.
| SNP | Series | Minor allele frequency | Common homozygote n (%)a | Heterozygote n (%)a | Rare homozygote n (%)a | Number genotyped | P-trend | P-het |
|---|---|---|---|---|---|---|---|---|
| rs1981434 | Cases | 0.28 | 1114 (51) | 866 (40) | 191 (9) | 2171 | ||
| Controls | 0.29 | 1171 (52) | 905 (40) | 188 (8) | 2264 | 0.66 | 0.84 | |
| OR (95% CI) | 1 (ref) | 1.01 (0.89–1.14) | 1.07 (0.86–1.33) | |||||
| rs2854345 | Cases | 0.19 | 1309 (65) | 631 (31) | 66 (3) | 2006 | ||
| Controls | 0.18 | 1489 (68) | 625 (29) | 77 (3) | 2191 | 0.15 | 0.12 | |
| OR (95% CI) | 1 (ref) | 1.15 (1.01–1.31) | 0.98 (0.70–1.37) | |||||
| rs520342 | Cases | 0.25 | 1121 (56) | 759 (38) | 126 (6) | 2006 | ||
| Controls | 0.25 | 1232 (57) | 793 (36) | 149 (7) | 2174 | 0.93 | 0.56 | |
| OR (95% CI) | 1 (ref) | 1.05 (0.93–1.20) | 0.93 (0.72–1.19) | |||||
| rs399413 | Cases | 0.29 | 1032 (51) | 819 (41) | 164 (8) | 2015 | ||
| Controls | 0.27 | 1157 (53) | 855 (39) | 164 (8) | 2176 | 0.20 | 0.42 | |
| OR (95% CI) | 1 (ref) | 1.07 (0.95–1.22) | 1.12 (0.89–1.41) | |||||
| rs4151540 | Cases | 0.28 | 1144 (53) | 865 (40) | 168 (8) | 2177 | ||
| Controls | 0.27 | 1220 (54) | 874 (38) | 179 (8) | 2273 | 0.63 | 0.68 | |
| OR (95% CI) | 1 (ref) | 1.06 (0.93–1.19) | 1.00 (0.80–1.25) | |||||
| rs198610 | Cases | 0.03 | 1893 (93) | 131 (6) | 3 (<1) | 2027 | ||
| Controls | 0.03 | 2081 (94) | 129 (6) | 3 (<1) | 2213 | 0.43 | 0.69 | |
| OR (95% CI) | 1 (ref) | 1.12 (0.87–1.43) | 1.10 (0.22–5.45) | |||||
| rs2227311 | Cases | 0.13 | 1548 (76) | 452 (22) | 41 (2) | 2041 | ||
| Controls | 0.14 | 1645 (74) | 521 (24) | 49 (2) | 2215 | 0.25 | 0.49 | |
| OR (95% CI) | 1 (ref) | 0.92 (0.80–1.06) | 0.89 (0.58–1.35) | |||||
| rs2854344 | Cases | 0.07 | 3634 (87) | 542 (13) | 23 (1) | 4199 | ||
| Controls | 0.08 | 3738 (84) | 659 (15) | 29 (1) | 4426 | 0.007 | 0.023 | |
| OR (95% CI) | 1 (ref) | 0.80 (0.75–0.96) | 0.82 (0.47–1.41) | |||||
| rs9535032 | Cases | 0.29 | 1020 (50) | 830 (41) | 180 (9) | 2030 | ||
| Controls | 0.29 | 1134 (51) | 884 (40) | 189 (9) | 2207 | 0.48 | 0.76 | |
| OR (95% CI) | 1 (ref) | 1.04 (0.92–1.19) | 1.06 (0.85–1.32) | |||||
| rs425834 | Cases | 0.03 | 2052 (94) | 135 (6) | 5 (<1) | 2192 | ||
| Controls | 0.03 | 2138 (94) | 135 (6) | 3 (<1) | 2276 | 0.62 | 0.71 | |
| OR (95% CI) | 1 (ref) | 1.04 (0.81–1.33) | 1.74 (0.41–7.28) | |||||
| rs198580 | Cases | 0.02 | 4001 (95) | 186 (4) | 4 (<1) | 4191 | ||
| Controls | 0.03 | 4187 (94) | 251 (6) | 3 (<1) | 4441 | 0.018 | 0.033 | |
| OR (95% CI) | 1 (ref) | 0.78 (0.64–0.94) | 1.40 (0.31–6.24) | |||||
| rs4151611 | Cases | 0.05 | 3955 (91) | 391 (9) | 8 (<1) | 4354 | ||
| Controls | 0.04 | 4160 (91) | 387 (8) | 7 (<1) | 4554 | 0.38 | 0.68 | |
| OR (95% CI) | 1 (ref) | 1.06 (0.92–1.23) | 1.20 (0.44–3.32) | |||||
| rs4151620 | Cases | 0.13 | 1537 (76) | 450 (22) | 39 (2) | 2026 | ||
| Controls | 0.14 | 1628 (75) | 510 (23) | 39 (2) | 2177 | 0.55 | 0.62 | |
| OR (95% CI) | 1 (ref) | 0.93 (0.81–1.08) | 1.06 (0.67–1.66) | |||||
| rs3092904 | Cases | 0.26 | 1118 (55) | 785 (38) | 139 (7) | 2042 | ||
| Controls | 0.26 | 1227 (56) | 822 (37) | 154 (7) | 2203 | 0.71 | 0.75 | |
| OR (95% CI) | 1 (ref) | 1.05 (0.92–1.19) | 0.99 (0.78–1.26) | |||||
| rs4151636 | Cases | 0.05 | 1996 (91) | 187 (9) | 5 (<1) | 2188 | ||
| Controls | 0.04 | 2092 (92) | 181 (8) | 4 (<1) | 2277 | 0.45 | 0.71 | |
| OR (95% CI) | 1 (ref) | 1.08 (0.87–1.34) | 1.31 (0.35–4.89) |
a
Rounded to the nearest unit.
OR, odds ratio; CI, confidence interval.