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. 2006 May 23;94(12):1936–1941. doi: 10.1038/sj.bjc.6603177

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Copyright © 2006 Cancer Research UK

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Granulocyte chemotactic protein-2 is an autocrine mitogen for SCLC cells. (A) After SCLC cells were treated with neutralising anti-GCP-2 antibody for 48 h, cell proliferation was significantly inhibited by 26% (P<0.01) in H711 and by 21% (P<0.05) in H345, but not affected in H69, GLC19 and Lu165. Each bar is the mean±s.e.m. of three determinations from two independent experiments. (B) The expression of PCNA was measured by flow cytometry following the treatment of exogenous GCP-2. The results are expressed as the mean fluorescent intensity. rGCP-2 (0.1–10 ng ml⁻¹) upregulated the expression of PCNA in dose-dependent manner in two low-GCP-2-producing cell lines H69 and GLC19. In contrast, expression of PCNA was not increased after rGCP-2 treatment in high-GCP-2-producing cell lines H711 and H345, or in Lu165.