Table 7. Efaproxiral survival effect by prognostic factors and E-RBC group for all eligible breast cancer patients.

		Hazard ratio vs control
Prognostic factor	Level	Low E-RBC	High E-RBC	All patients
RPA class	I	Non-esta	0.17	0.36
	II	0.61	0.31	0.56
Primary tumour control	Yes	0.73	0.16	0.54
	No	0.55	0.31	0.52
Age (years)	<65	0.56	0.26	0.55
	>65	0.76	Non-esta	0.35
Extra-cranial metastases	Yes	0.61	0.28	0.43
	No	1.03	Non-esta	0.63
KPS	90–100	0.88	0.24	0.58
	<90	0.47	0.28	0.52
Number of brain lesions	1	0.39	Non-esta	0.36
	2	0.93	0.38	0.65
	3	0.64	0.31	0.54

^aNon-estimatable due to low number of events in the efaproxiral group.

E-RBC=efaproxiral red blood cell concentration; RPA=recursive partitioning analysis; KPS=karnofsky performance status.