Table 1. Main characteristics of the studies relating microvessel density to MVD survival.
| First author Year of issue (reference) | Study from PubMed | Study design | N (M/F) | Colon (n) | Rectum (n) | Blinded reading | Reader(s) (n) | Mode of reading | Antibody | Extension | RR estimate | Survival analysis | Results |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Galizia et al (2004) | Yes | C | 104 (73/31) | 104 | 0 | Yes | 2 | Optical | CD34 | Limited | Given by authors | OS, RFS | Negative |
| Lackner et al (2004) | Yes | R | 70 (39/31) | 49 | 21 | ? | ? | Optical | FVIII CD34 | Mixed | Missing | ? | Positive |
| Liang et al (2004) | No | C | 114 (60/54) | 77 | 37 | Yes | 1 | Optical | CD34 | Advanced | Reported in text | RFS | Positive |
| Kaio et al (2003a, 2003b) | Yes | R | 152 (94/58) | ? | ? | ? | ? | Optical | CD34 | Mixed | Survival curves | OS | Negative |
| Prall et al (2003) | Yes | C | 173 (87/86) | ? | ? | ? | 1 | Optical | FVIII | Mixed | Survival curves | OS | Inverse |
| Li et al (2003) | Yes | R | 111 (65/46) | 83 | 28 | ? | ? | Chalkley | CD105 CD34 | Mixed | Survival curves | OS | Positive |
| Shan et al (2003) | Yes | C | 104 (55/49) | 72 | 32 | Yes | 2 | Optical | FVIII | Limited | Data extrapolated | OS, RFS | Negative |
| Zheng et al (2003) | Yes | R | 97 (58/39) | ? | ? | ? | ? | Optical | CD34 | Mixed | Reported in text | OS | Positive |
| Cianchi et al (2002) | Yes | R | 84 (60/24) | 0 | 84 | Yes | 2 | Optical | CD31 | Limited | Data extrapolated | OS | Negative |
| Nanni et al (2002) | No | P | 263 (137/126) | 263 | 0 | Yes | 2 | Optical | FVIII | Mixed | Data extrapolated | OS, RFS | Negative |
| White et al (2002) | Yes | R | 84 (42/42) | 62 | 22 | Yes | 2 | Chalkley | CD31 FVIII | Limited | Missing | OS, RFS | Inverse |
| Sokmen et al (2001) | Yes | R | 29 (18/11) | 0 | 29 | Yes | 2 | Automated | FVIII | Mixed | Survival curves | OS | Positive |
| Galindo-Gallego et al (2000) | Yes | R | 126 (70/56) | 87 | 39 | ? | ? | Optical | CD34 | Limited | Survival curves | OS, RFS | Negative |
| Pietra et al (2000) | Yes | C | 119 (62/57) | 78 | 41 | Yes | 2 | Optical | CD31 | Mixed | Missing | OS, RFS | Negative |
| Van Triest et al (2000) | Yes | R | 32 (13/19) | 26 | 6 | Yes | 2 | Optical | CD31 | Mixed | Missing | Missing | ND |
| Giatromanolaki et al (2002) | No | R | 106 (65/41) | 77 | 29 | ? | ? | Optical | CD31 | Mixed | Missing | OS | Positive |
| Ishikawa et al (1999) | Yes | C | 57 (34/23) | 0 | 57 | Yes | 2 | Optical | CD31 | Limited | Survival curves | RFS | Positive |
| Sternfeld et al (1999) | Yes | R | 146 (?) | 70 | 76 | ? | 1 | Optical | CD31 | Limited | Survival curves | OS | Positive |
| Vermeulen et al (1999) | No | C | 145 (75/70) | 109 | 36 | ? | ? | Optical | CD31 | Advanced | Reported in text | RFS | Positive |
| Choi et al (1998) | Yes | R | 127 (72/55) | ? | ? | Yes | 2 | Optical | FVIII | Advanced | Survival curves | OS, RFS | Positive |
| Fox et al (1998) | Yes | R | 36 (14/22) | 36 | 0 | ? | ? | Optical | FVIII | ND | Survival curves | OS | Negative |
| Pavlopoulos et al (1998) | Yes | R | 106 (56/50) | ? | ? | Yes | ? | Automated | FVIII | Limited | Missing | Missing | Negative |
| Tanigawa et al (1997) | Yes | R | 133 (76/57) | ? | ? | Yes | 2 | Optical | CD34 | Advanced | Reported in text | OS | Positive |
| Takahashi et al (1997) | No | R | 27 (12/15) | 27 | 0 | Yes | 1 | Optical | FVIII | Limited | Survival curves | RFS | Positive |
| Engel et al (1996) | No | R | 35 (21/14) | ? | ? | Yes | 2 | Optical | CD31 | Limited | Data extrapolated | RFS | Positive |
| Lindmark et al (1996) | No | C | 212 (90/122) | 124 | 88 | Yes | 1 | Optical | FVIII | Limited | Data extrapolated | OS | Inverse |
| Mooteri et al (1996) | Yes | R | 32 (?) | ? | ? | Yes | ? | Optical | FVIII | Advanced | Missing | Missing | Negative |
| Takebayashi et al (1996) | Yes | R | 166 (108/58) | ? | ? | Yes | 2 | Optical | FVIII | Limited | Survival curves | OS | Positive |
| Tomisaki et al (1996) | No | R | 175 (98/77) | ? | ? | ? | 1 | Optical | FVIII | Advanced | Data extrapolated | OS | Negative |
| Frank et al (1995) | Yes | R | 105 (53/52) | 105 | 0 | Yes | ? | Optical | FVIII | Limited | Missing | Missing | Positive |
| Bossi et al (1995) | Yes | R | 178 (?) | ? | ? | ? | 1 | Optical | CD31 | Mixed | Missing | Missing | Negative |
| Saclarides et al (1994) | Yes | R | 48 (33/15) | 0 | 48 | Yes | 1 | Optical | FVIII | Mixed | Missing | Missing | ND |
C corresponds to studies including consecutive patients, R to retrospective studies without inclusion of consecutive patients. Extension means a predominance of limited forms (A/B), of advanced forms (C/D) or a balance between limited and advanced forms among the same study (mixed). RR estimate was either reported in text, or provided by mail by authors, or extrapolated from the data provided by authors in text, or estimated from the survival curves. A positive result means that there was an inverse relationship between MVD and survival, an inverse result means that there was a direct relationship between MVD and survival, and a negative result that there is no relationship. ‘Readers’ are readers of the histologic slides, ‘blinded reading’ means that readers of the slides were unaware of the clinical outcome of patients, and ‘?’ corresponds to missing data.