Table 2. Genes (n=50 of 167 probesetsa) identified as upregulated in MOC compared to other histological subtypes of ovarian cancer (ranked by adjusted P<0.01).
| Rank | Symbolb | Name | Unigenec | Locus link | Location |
|---|---|---|---|---|---|
| 1 | LGALS4 | Lectin, galactoside-binding, soluble, 4 (galectin 4) | Hs.5302 | 3960 | 19q13.2 |
| 2 | cDNA clone IMAGE:5759948, partial cds | Hs.447537 | NA | 15q15.1 | |
| 3 | Hypothetical protein MGC32871 | Hs.242014 | 119467 | 10q26.3 | |
| 4 | MUCDHL | Mucin and cadherin-like | Hs.165619 | 53841 | 11p15.5 |
| 5 | apobec-1 complementation factor | Hs.8349 | 29974 | 10q21.1 | |
| 6 | CDH17 | Cadherin 17, LI cadherin (liver-intestine) | Hs.89436 | 1015 | 8q22.1 |
| 7 | MEP1A | Meprin A, alpha (PABA peptide hydrolase) | Hs.179704 | 4224 | 6p12-p11 |
| 8 | MUC13 | Mucin 13, epithelial transmembrane | Hs.5940 | 56667 | 3q21 |
| 9 | FABP1 | Fatty acid binding protein 1, liver | Hs.380135 | 2168 | 2p11 |
| 10 | MUC3B | Mucin 3B, intestinal | Hs.489354 | NA | 7q22 |
| 11 | CEACAM5 | CEA-related cell adhesion molecule 5 (CEA) | Hs.220529 | 1048 | 19q13.2 |
| 12 | PDZK2 | PDZ domain containing 2 | Hs.374726 | 79849 | 11q23.3 |
| 13 | GPA33 | Glycoprotein A33 (transmembrane) | Hs.437229 | 10223 | 1q24.1 |
| 14 | RNF128 | Ring finger protein 128 | Hs.496542 | 79589 | Xq22.3 |
| 15 | MUCDHL | Mucin and cadherin-like | Hs.165619 | 53841 | 11p15.5 |
| 16 | EPS8L3 | EPS8-like 3 | Hs.485352 | 79574 | 1p13.2 |
| 17 | BCL2L14 | BCL2-like 14 (apoptosis facilitator) | Hs.504794 | 79370 | 12p13.2 |
| 18 | SYTL2 | Synaptotagmin-like 2, transcript variant a | Hs.369520 | 54843 | 11q14.1 |
| 19 | HMGCS2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | Hs.59889 | 3158 | 1p13-p12 |
| 20 | FAM3D | Family with sequence similarity 3, member D | Hs.61265 | 131177 | 3p21.2 |
| 21 | MYO1A | Myosin IA | Hs.5394 | 4640 | 12q13.3 |
| 22 | SLC26A3 | Solute carrier family 26, member 3 | Hs.1650 | 1811 | 7q31 |
| 23 | ATP10B | ATPase, Class V, type 10B | Hs.109358 | 23120 | 5q34 |
| 24 | BTNL8 | Butyrophilin-like 8 | Hs.189109 | 79908 | 5q35.3 |
| 25 | MYO7B | Myosin VIIB | Hs.154578 | 4648 | 2q14.3 |
| 26 | CDX1 | Caudal type homeo box transcription factor 1 | Hs.1545 | 1044 | 5q33.1 |
| 27 | cDNA clone IMAGE:4661388, partial cds | Hs.306721 | 400573 | 17p13.1 | |
| 28 | ESTs; moderate similarity to protein P39188 (H.sapiens) | Hs.282795 | NA | 10q11.23 | |
| 29 | ESTs | Hs.116462 | NA | 20q13.12 | |
| 30 | Cisplatin resistance associated | Hs.425144 | 10903 | 1q21.2 | |
| 31 | TRIM31 | Tripartite motif-containing 31 | Hs.493275 | 11074 | 6p21.3 |
| 32 | UGT1A9 | UDP glycosyltransferase 1 family, polypeptide A9 | Hs.124112 | 54600 | 2q37 |
| 33 | ACHE | Acetylcholinesterase (YT blood group) | NA | 43 | 7q22 |
| 34 | PLA2G10 | Phospholipase A2, group X | Hs.144442 | 401831 | 16p13.1-p12 |
| 35 | Hypothetical protein LOC144347 | Hs.432901 | 144347 | 12q24.31 | |
| 36 | GUCY2C | Guanylate cyclase 2C (heat stable enterotoxin receptor) | Hs.524278 | 2984 | 12p12 |
| 37 | cDNA clone IMAGE:4806358, partial cds | Hs.328236 | NA | 4q32.3 | |
| 38 | PLAC8 | Placenta-specific 8 | Hs.371003 | 51316 | 4q21.3 |
| 39 | KIAA0828 protein | Hs.195058 | 23382 | 7q32.3 | |
| 40 | COL17A1 | Collagen, type XVII, alpha 1 | Hs.117938 | 1308 | 10q25.1 |
| 41 | CLCA1 | Chloride channel, calcium activated, family member 1 | Hs.194659 | 1179 | 1p31-p22 |
| 42 | Hypothetical protein FLJ20225 | Hs.124835 | 54546 | 1p36.13 | |
| 43 | TM4SF4 | Transmembrane 4 superfamily member 4 | Hs.133527 | 7104 | 3q25 |
| 44 | MUC17 | mucin 17 | Hs.271819 | 140453 | 7q22 |
| 45 | FA2H | Fatty acid 2-hydroxylase | Hs.461329 | 79152 | 16q23 |
| 46 | HNF4A | Hepatocyte nuclear factor 4, alpha | Hs.116462 | 3172 | 20q12-q13.1 |
| 47 | SEMA4G | Sema domain, immunoglobulin domain, transmembrane domain and short cytoplasmic domain, (semaphorin) 4G | Hs.444359 | 57715 | 10q24.32 |
| 48 | cDNA FLJ26898 fis, clone RCT00475 | Hs.199371 | NA | 11q13.1 | |
| 49 | C9orf152 | Chromosome 9 open reading frame 152 | Hs.125608 | 401546 | 9q32 |
| 50 | S100P | S100 calcium binding protein P | Hs.2962 | 6286 | 4p16 |
Full list of genes are listed in Supplementary Data.
HUGO.
Unigene identifiers were derived from the UniGene Build #176 (October 2004).