Table 2. Activities of manganese, copper and zinc superoxide dismutases, catalase and glutathione peroxidase in serum or tumour tissues of mice orally or intraperitoneally treated with oxykine, gliadin, melon SOD or saline.
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Antioxidative enzyme activities mg−1 protein in
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|---|---|---|---|---|---|---|---|
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Tumour tissues
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Serum
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| Treatmenta | Route of administration | Mn-SOD (U) | CuZn-SOD (U) | Catalase (U) | GPx (mU) | Mn-SOD (U) | CuZn-SOD (U) |
| Saline | Per oral | 2.3±1.2b | 12.9±3.0 | 36.2±4.0 | 78.3±12.9 | 1.7±0.3 | 14.2±1.4 |
| Gliadin | Per oral | 2.7±0.5 | 15.6±1.7 | 35.8±11.8 | 79.5±8.7 | 1.7±0.5 | 14.2±0.4 |
| Melon SOD | Per oral | 2.9±0.4 | 14.7±1.1 | 35.0±12.1 | 79.8±10.0 | 1.7±0.5 | 13.6±2.0 |
| Oxykine | Per oral | 5.1±1.1b | 14.3±3.3 | 35.8±25.8 | 77.3±38.2 | 1.8±0.6 | 14.7±2.2 |
| Saline | Intraperitoneal | 2.7±0.7 | 15.5±2.6 | 33.3±8.4 | 83.7±39.0 | 2.3±1.2 | 13.9±1.5 |
| Gliadin | Intraperitoneal | 2.2±0.8 | 13.8±2.7 | 28.5±8.6 | 66.6±27.0 | 1.9±0.6 | 14.9±0.7 |
| Melon SOD | Intraperitoneal | 2.9±0.4 | 14.9±0.7 | 30.3±6.7 | 85.5±10.8 | 1.5±0.3 | 13.8±0.8 |
| Oxykine | Intraperitoneal | 2.5±0.3 | 15.3±2.9 | 32.3±12.4 | 83.3±2.5 | 2.7±1.2 | 12.3±2.1 |
a
1 × 105 QR-32 tumour cells were coimplanted with gelatine sponge in normal mice to which oxykine, gliadin, melon SOD had been administered orally or intraperitoneally (10 mg kg−1) every day from 2 days before coimplantation to the end of the experiment. All the mice were killed under ether anaesthesia at 28 days after implantation, and serum and tumour tissues were collected for examination.
b
P<0.01 vs saline group.