Table 2. Drug-related adverse events by NCI CTC grade.

	All (n=17)
Grade 3
Leucopenia	1
Neutropenia	3
WBC decreased	1
Grade 2
Leucopenia	2
Thrombocytopenia	2
Nausea	2
WBC count decreased	1
Skin disorders	6
Hypotension	1
Grade 1
Fever	4
Thrombocytopenia	1
Headache	1
Skin disorders	7
Folliculitis	1

DLT=dose-limiting toxicity; NCI CTC=National Cancer Institute Common Toxicity Criteria; WBC=white blood cell.

DLT was defined as grade 3 or 4 nonhaematologic toxicities (excluding headache, alopecia, nausea, vomiting, skin reactions, and fever above 40°C for less than 24 h); grade 4 nausea, vomiting, fever above 40°C sustained for more than 24 h; grade 3 or 4 neutropenia associated with complications (e.g. neutropenic fever); grade 4 thrombocytopenia, toxicity-related discontinuation of treatment for more than 1 week within the first two treatment cycles.