Table 3. Haematologic and nonhaematologic toxicity: highest WHO grade for each patient.
|
Toxicity
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dose-dense-schedule group | Conventional-schedule group | |||||||||
|
WHO gradea (n (%))
|
WHO gradea (n (%))
|
|||||||||
| n | 0 | 1 or 2 | 3 | 4 | n | 0 | 1 or 2 | 3 | 4 | |
| Haematologic | ||||||||||
| Leukopenia | 108 | 10 (9%) | 50 (46%) | 40 (37%) | 8 (7%) | 107 | 8 (7%) | 47 (44%) | 46 (43%) | 6 (6%) |
| Neutropenia | 77 | 9 (12%) | 20 (26%) | 26 (34%) | 22 (29%) | 82 | 12 (15%) | 17 (21%) | 23 (28%) | 30 (37%) |
| Thrombocytopenia | 107 | 82 (77%) | 22 (21%) | 3 (3%) | 0 | 107 | 97 (91%) | 10 (10%) | 0 | 0 |
| Anaemia | 108 | 14 (13%) | 90 (83%) | 4 (4%) | 0 | 107 | 42 (39%) | 64 (60%) | 1 (1%) | 0 |
| Nonhaematologic | ||||||||||
| Alopecia | 108 | 6 (6%) | 16 (15%) | 86 (80%) | 0 | 107 | 4 (4%) | 14 (13%) | 89 (83%) | 0 |
| Nausea/vomiting | 108 | 14 (13%) | 87 (81%) | 7 (6%) | 0 | 107 | 10 (9%) | 85 (79%) | 11 (10%) | 1 (1%) |
| Fatigue | 108 | 42 (39%) | 58 (54%) | 8 (7%) | 0 | 107 | 52 (48%) | 52 (49%) | 3 (3%) | 0 |
| Mucositis | 108 | 57 (53%) | 42 (39%) | 9 (8%) | 0 | 107 | 60 (56%) | 45 (42%) | 2 (2%) | 0 |
| Bone pain | 108 | 60 (56%) | 43 (40%) | 5 (5%) | 0 | 107 | 82 (76%) | 22 (21%) | 2 (2%) | 1 (1%) |
| PNS toxicity | 108 | 57 (53%) | 50 (46%) | 1 (1%) | 0 | 107 | 95 (88%) | 11 (10%) | 1 (1%) | 0 |
| Arthralgia/myalgia | 108 | 84 (78%) | 20 (19%) | 4 (4%) | 0 | 107 | 91 (84%) | 16 (15%) | 0 | 0 |
PNS=peripheral nervous system; WHO=World Health Organization.
a
Because of rounding, percentages may not total 100%.