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The effect of an IKr agonist to abbreviate action potential duration and QT interval and augment transmural dispersion of repolarization (TDR). A: Control. B: PD-118057 (10 µmol/L). Each panel shows transmembrane action potentials simultaneously recorded from an epicardial (Epi) and a deep subendocardial M-cell in an arterially perfused LV wedge preparation, together with a pseudo-ECG. Basic cycle length (BCL) =2000 ms.
