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IKr agonist-induced short QT and polymorphic ventricular tachycardia (pVT). A: Control B: PD-118057 (10 µmol/L). C: PD-118057 (10 µM)+ quinidine (10 µM). Programmed electrical stimulation applied to the LV wedge preparation induced pVT when the QT interval and the effective refractory period were abbreviated with the IKr agonist, but not under baseline conditions or after the addition of quinidine. BCL = 2000 ms.
