Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2009 Apr 1.

Published in final edited form as: Heart Rhythm. 2008 Jan 29;5(4):585–590. doi: 10.1016/j.hrthm.2008.01.022

Table 1.

Effect of the I_Kr agonist PD-118057 on QT interval, TDR, pVT inducibility in the absence and presence of quinidine

	QT interval (ms)		TDR (ms)		pVT
	Endo Stimulation	Epi Stimulation	Endo Stimulation	Epi Stimulation	Endo Stimulation	Epi Stimulation
Control (n=16–20)	269.2±4.8	282.2±5.1^*	34.1±2.0	57.7±3.3^*	0/20	0/20
PD-118057 (n=16–20)	232.3±4.1^†	258.1±5.4^*^†	46.9±3.7^†	77.6±4.3^*^†	0/20	10/20
Control (n=7)	277.7±8.8	290.2±9.6^*	36.4±4.3	63.6±6.4^*	0/7	0/7
PD-118057 (n=7)	242.9±8.1^†	266.9±9.9^*^†	55.1±5.2^†	89.0±6.4^*^†	0/7	5/7
PD-118057 + Quinidine (n=7)	298±11.2^‡	319.3±9.7^*^†^‡	46.9±3.5	83.4±5.8^*^†	0/7	0/7

pVT = polymorphic ventricular tachycardia. TDR = transmural dispersion of repolarization. BCL = 2000 ms.

^*

p<0.05 vs. Endo Stimuli

^†

p<0.05 vs. Control

^‡

p<0.05 vs. PD-118057.