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. 2008 Jan 8;98(2):335–344. doi: 10.1038/sj.bjc.6604082

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Copyright © 2008 Cancer Research UK

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Effect of AS602868 combined with CPT-11 on necrosis, cell proliferation, and cell cycle progression in HT-29 cells and tumours. (A) Histological examination of HT-29 tumour xenografts after 6 (control and AS602868 groups) or 10 weeks of treatment (CPT-11 and CPT-11+AS60286 groups). Tumour sections were stained with HES (necrosis) or anti-Ki-67 (proliferation staining). Magnification: × 320. (B) Quantification of AS602868±SN-38 effect on HT-29 cancer cell proliferation by ELISA based on BrdU incorporation in DNA. (C) Measure of AS602868±SN-38 effect on cell cycle progression by flow cytometric analyses using propidium iodide staining. Cells were stimulated for 72 h after adhesion. ^* indicates detection of the synergistic effect of AS602868 and SN-38 by using the non-constant ratio isobologram method.