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. 2008 Jan 22;98(2):410–417. doi: 10.1038/sj.bjc.6604124

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Copyright © 2008 Cancer Research UK

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Genetic alterations of the GNG7-coding region. (A) Two representative oesophageal cancer cases that were positive (left) or negative (right) for LOH. (B) Results of pyrosequencing analysis in a CG-rich region. Region #2 did not show any alterations by bisulphite treatment. However, region #1 showed that nucleotide C was increased in tumour tissues relative to corresponding normal tissue, and nucleotide T was decreased in tumour compared to corresponding normal tissue. This trial focused on the CG site with cancer-specific CG arrangements. (C) Classification of 42 cases of oesophageal cancer according to LOH status at GNG7 region and/or promoter hypermethylation. No genetic and/or epigenetic alterations were detected in eight cases (100%) of oesophageal cancer that lacked suppression of GNG7 (T/N<0.8) expression. In contrast, LOH and/or hypermethylation were found in 22 out of 34 cases (65%) with diminished GNG7 expression.