Table 2. Partial pressure of oxygen (pO2) measured by EPR oximetry in SA-1 tumours and subcutis before the treatment of tumours and 2 h after treatment by electric pulses, bleomycin and electrochemotherapy.
| Pretreatment values | Bleomycina | Electric pulsesb | Electrochemotherapyc | |
|---|---|---|---|---|
| Tissue/therapy | (mmHg, AM±s.e.) | (mmHg, AM±s.e.) | (mmHg, AM±s.e.) | (mmHg, AM±s.e.) |
| Subcutis | 8.37±0.05 | 7.35±0.09d | 7.66±0.08d | 5.90±0.17d |
| Tumour periphery | 7.33±0.09 | 4.93±0.19d | 2.16±0.07d | 2.11±0.13d |
| Tumour centre | 5.35±0.05 | 4.58±0.07d | 2.68±0.14d | 1.39±0.12d |
EPR=electron paramagnetic resonance.
a
Bleomycin injected intravenously (1 mg kg−1).
b
Application of electric pulses to the tumour (8 pulses, 1040 V, 100 μs, 1 Hz).
c
Electrochemotherapy: application of electric pulses to the tumour 3 min after intravenous injection of bleomycin.
d
P-values (<0.05) for different treatments vs normal values.