Table 6. Summary of the major findings.
Trend (P<0.05)
|
|||||
---|---|---|---|---|---|
Cancer sites (ICD 9th revision) | With time since NHL diagnosis | With age at NHL diagnosis | With calendar period at NHL diagnosis | Risk of NHL as a second primary cancer and trend with time since the first cancer (P<0.05) | Comments |
Lip (140) | — | — | ↗ | 1.16 (0.96–1.38) No trend | Common exposure or mechanism |
Tongue (141) | — | — | — | 1.43 (0.95–2.06) No trend | Common exposure or mechanism |
Oropharynx (146) | — | — | — | 2.75 (1.84–3.94) No trend | Common exposure or mechanism |
Stomach (151) | ↗ | ↘ | — | 1.14 (0.97–1.34) ↗ | Treatment effect or misclassification of extranodal NHL |
Small intestine (152) | — | — | — | 1.36 (0.81–2.15) No trend | Detection bias |
Colon (153) | — | — | — | 1.16 (1.06–1.26) No trend | Misclassification of extranodal NHL |
Liver (155) (−155.2) | — | — | — | 0.79 (0.26–1.85) No trend | Common exposure or mechanism |
Nose and nasal cavity (160) | — | — | — | 1.79 (1.14–2.69) No trend | Common exposure or mechanism |
Lung (162) | ↗ | ↘ | — | 1.12 (0.98–1.27) No trend | Treatment effect +common exposure |
Soft tissue sarcoma (171) | — | — | — | 1.84 (1.43–2.33) No trend | Common exposure or mechanism |
Melanoma of skin (172) | ↘ | — | — | 1.42 (1.29–1.57) ↘ | Common exposure or mechanism |
Other neoplasm of skin (173) | — | — | — | 1.90 (1.79–2.01) ↘ | Common exposure or mechanism |
Bladder (188, 189.3, 189.4) | ↗ | ↘ | — | 1.15 (1.04–1.26) No trend | Treatment effect +common exposure |
Kidney (189) (−189.3, 189.4) | — | — | ↗ | 1.25 (1.07–1.46) No trend | Detection bias |
Thyroid gland (193) | — | — | — | 1.68 (1.37–2.04) No trend | Common exposure or mechanism |
Hodgkin's disease (201) | ↗ | ↘ | — | 6.30 (5.39–7.32) No trend | Treatment, common exposure or misclassifciation |
Lymphoid leukaemia (204) | — | ↘ | — | 3.19 (2.76–3.67) No trend | Misclassification and common exposure |
Myeloid leukaemia (205) | — | ↘ | — | 1.54 (0.96–2.33) No trend | Treatment effect |
NHL, non-Hodgkin's lymphoma.