Table 2. Summary of all patients and treatment administered.
|
Cycle # and dose of PEG-LD (mg m−2)
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient # | 1a | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| 1 | 20 | 8 | 12 | 16 | 20 | |||||||||
| 2 | 20 | 16 | 20 | 24 | 18 | 18 | 18 | 18 | 18 | 13.5 | 13.5 | 13.5 | 13.5 | 13.5 |
| 3 | 20 | 20 | 20 | 20 | ||||||||||
| 4 | 20 | 20 | ||||||||||||
| 5 | 20 | 20 | ||||||||||||
| 6 | 20 | 22 | 22 | 16.5 | 16.5 | 16.5 | 16.5 | 12.4 | 12.4 | 12.4 | 12.4 | 12.4 | ||
| 7 | 22 | 22 | 22 | 22 | ||||||||||
| 8 | 22 | 22 | 22 | 22 | ||||||||||
| 9 | 25 | 25 | 25 | 25 | ||||||||||
| 10 | 25 | 25 | ||||||||||||
| 11 | 25 | 25 | ||||||||||||
| 12 | 25 | 25 | 25 | 25 | 18.75 | 18.75 | 18.75 | 18.75 | 18.75 | 18.75 | 18.75 | 18.75 | ||
| 13 | 25 | 25 | ||||||||||||
| 14 | 25 | 25 | 25 | 25 | 25 | 18.75 | 18.75 | 18.75 | 18.75 | 18.75 | 14.06 | 14.06 | 14.06 | 14.06 |
All patients received PEG-LD (pegylated liposomal doxorubicin) alone for the cycle 1 and PEG-LD in combination with valspodar for all other cycles.