Table 5. Cox regression analysis of potential factors predictive of overall survival (defined as period from date Iressa started till last follow-up date or death).

	Coefficient (s.e.)	Hazards ratio	95% confidence interval	P-value
Gender
Female (n=58)	−0.04 (0.29)	0.96	0.54, 1.70	0.88
Male (n=52)	—	1	—
Smoker
No (n=66)	−0.12 (0.31)	0.88	0.48, 1.63	0.69
Yes (n=44)	—	1	—
Age in years
<60 (n=65)	0.14 (0.30)	1.15	0.64, 2.08	0.63
⩾60 (n=45)	—	1	—
No. of lines of chemotherapy
0–1 (n=32)	−0.29 (0.31)	0.75	0.41, 1.38	0.36
⩾2 (n=78)	—	1	—
ECOG status
0–1 (n=79)	−0.86 (0.27)	0.42	0.25, 0.72	0.002
2–4 (n=31)	—	1	—
Squamous cell histology
No (n=99)	−0.27 (0.45)	0.77	0.32, 1.84	0.55
Yes (n=11)	—	1	—
Response
SD/PD (n=75)	1.09 (0.34)	2.98	1.54, 5.77	0.001
CR/PR (n=35)	—	1	—