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. 2005 Oct 25;93(10):1085–1091. doi: 10.1038/sj.bjc.6602839

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Copyright © 2005 Cancer Research UK

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The chimeric immune receptor. (A) The T-cell receptor composed of the α and β chains transmits its signal through the CD3 molecule (γ, ε, δ and ζ moieties) following interaction with MHC/epitope complex. This differs from the chimeric immune receptor (B) which is composed of an extracellular single chain antibody recognition domain connected to signalling moiety shown in this example as either the CD3 ζ molecule (C) or as a fusion receptor using the CD28 molecule proximal to the ζ moiety. Activation of the chimeric immune receptor can be initiated in the presence of tumour antigen in an MHC independent manner.