Table 4c. Mean (s.d.) pharmacokinetic parameters of tipifarnib (200 mg) as monotherapy, or with gemcitabine (750–1000 mg m−2) and cisplatin (75–100 mg m−2).
| Variable | Units | Tipifarnib (s.d.) n=20 | Tipifarnib+gem/cis (s.d.) n=23 | P-valuea |
|---|---|---|---|---|
| Tipifarnib | ||||
| Median tmax | Hours | 3.0 | 2.1 | — |
| Cmax | ng ml−1 | 499 (275) | 635 (366) | 0.094b |
| AUC0-12 | h ng ml−1 | 2630 (1134) | 2971 (2089)c | 0.918b |
a
Two-sided P-value in log-scale for testing a difference between the two treatments. Only data from patients who completed the study were included.
b
n=20.
c
n=22.
Gem=gemcitabine; cis=cisplatin.