Table 3. Toxicity per patient according to NCI-CTC grade.

	Oxaliplatin/raltitrexed (n=48)		Irinotecan/raltitrexed (n=46)
Toxicity	Grade 1–2	Grade 3–4	Grade 1–2	Grade 3–4
Neutropenia	3 (6%)	1 (2%)	5 (11%)	4 (8%)
Anaemia	8 (17%)	2 (4%)	11 (24%)	1 (2%)
Thrombocytopenia	4 (8%)	2 (4%)	3 (7%)	2 (4%)
Nausea/vomiting	20 (42%)	6 (12%)	20 (43%)	3 (7%)
Diarrhoea	11 (23%)	4 (8%)	18 (39%)	6 (13%)
Stomatitis	3 (6%)	—	3 (7%)	2 (4%)
Transaminases	25 (53%)	4 (8%)	19 (53%)	4 (9%)
Asthenia	15 (31%)	2 (4%)	21 (46%)	3 (7%)
Peripheral neuropathy	26 (54%)	5 (10%)	—	—
Alopecia	2 (4%)	—	13 (28%)	2 (4%)
Cholinergic syndrome	—	—	9 (19%)