Table 4. Number of patients with asymptomatic colorectal cancer in two trials having grade 3 or 4 toxicity.
|
Australasia
|
Canada
|
|||
|---|---|---|---|---|
| Immediate | Delayed | Immediate | Delayed | |
| Type of toxicity (n, %) | n=49a | n=31a | n=34a | n=26a |
| Nausea and vomiting | 3 (6) | 5 (16) | 6 (18) | 0 (0) |
| Stomatitis | 1 (2) | 4 (13) | 9 (26) | 4 (15) |
| Diarrhoea | 10 (20) | 5 (16) | 9 (26) | 4 (15) |
| Dermatitis | 0 (0) | 0 (0) | 0 (0) | 1 (4) |
| Infection | 4 (8) | 0 (0) | 3 (9) | 2 (8) |
| Other | 3 (6) | 2 (6) | 10 (29) | 12 (46) |
| Haemoglobin | 0 (0) | 1 (3) | 0 (0) | 2 (8) |
| White blood cells | 0 (0) | 0 (0) | 3 (9) | 5 (19) |
| Neutrophils | 4 (8) | 1 (3) | 8 (24) | 6 (23) |
| Platelets | 0 (0) | 1 (3) | 0 (0) | 0 (0) |
| Creatinine | 0 (0) | 0 (0) | 1 (3) | 0 (0) |
| Bilirubin | 1 (2) | 2 (6) | 0 (0) | 5 (19) |
| Alkaline phosphatase | 1 (2) | 7 (23) | 0 (0) | 1 (4) |
| Aspartate aminotransferase | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Lactate dehydrogenase | 7 (14) | 7 (23) | NA | NA |
NA=not applicable.
a
Number receiving protocol therapy.