Table 2. Standardised incidence ratios (SIRsa) for childhood acute lymphoblastic leukaemia in children with relatives diagnosed with different type of cancers.
|
Relatives affected
|
||||||
|---|---|---|---|---|---|---|
|
Parents only
|
Siblings only
|
|||||
| Cancer in relatives | Obs. | SIRs | (95% CI) | Obs. | SIRs | CI (95% CI) |
| Stomach | 7 | 1.32 | (0.53–2.73) | |||
| Colon | 11 | 0.89 | (0.44–1.60) | |||
| Rectum | 5 | 0.67 | (0.22–1.55) | |||
| Pancreas | 6 | 1.42 | (0.52–3.08) | |||
| Lung | 18 | 1.26 | (0.74–1.98) | |||
| Breast | 40 | 1.00 | (0.71–1.36) | 3 | 1.49 | (0.22–6.17) |
| Cervix | 7 | 1.02 | (0.41–2.10) | |||
| Endometrium | 7 | 1.43 | (0.57–2.94) | 1 | 6.51 | (0.12–51.34) |
| Ovary | 9 | 1.51 | (0.69–2.86) | |||
| Prostate | 24 | 1.09 | (0.70–1.62) | |||
| Testicular | 10 | 3.12 | (1.50–5.75) | 1 | 0.87 | (0.02–6.85) |
| Seminoma | 4 | 2.26 | (0.59–5.85) | |||
| Teratoma | 5 | 4.10 | (1.29–9.64) | |||
| Urinary bladder | 9 | 1.00 | (0.46–1.91) | |||
| Melanoma | 11 | 0.77 | (0.39–1.39) | 1 | 0.61 | (0.01–4.80) |
| Nervous system | 11 | 0.95 | (0.47–1.69) | 3 | 0.92 | (0.13–3.78) |
| Thyroid gland | 4 | 1.06 | (0.29–2.72) | 1 | 1.95 | (0.03–15.39) |
| Connective tissue | 5 | 2.38 | (0.77–5.56) | 1 | 2.08 | (0.04–16.37) |
| Non-Hodgkin's disease | 7 | 0.88 | (0.35–1.82) | |||
| Hodgkin's disease | 4 | 1.82 | (0.50–4.65) | 2 | 2.31 | (0.20–11.83) |
a
SIRs stratified by age and follow-up period.