Figure 1.

The relationship between the treatment effect on median survival time and each of the four surrogate markers. The regression lines are as follows, with the corresponding P-value, coefficient of determination (R²) and standard error of the regression coefficient (s.e.) in brackets: (A) Log₁₀ hazard ratio=−0.0081+0.2796 × log₁₀ odds ratio for complete/partial response (P<0.0001, R²=34%, s.e.=0.0590), (B) Log₁₀ hazard ratio=−0.0097+0.1266 × log₁₀ odds ratio for complete response (P=0.02, R²=12%, s.e.=0.0521), (C) Log₁₀ hazard ratio=0.0015–0.1781 × log₁₀ odds ratio for progressive disease (P<0.0001, R²=38%, s.e.=0.0380), (D) Log₁₀ hazard ratio=0.0135+0.5082 × log₁₀ ratio of median time to progression (P<0.001, R²=56%, s.e.=0.0928). The size of the symbols is proportional to the inverse of the variance (the weight). For time to progression the size is proportional to the number of patients in the trial.