Table 1. Patient characteristics and HER3 FISH status in NSCLC.
|
HER3 FISH status
|
||||
|---|---|---|---|---|
| Characteristics | Total N=82 No (%) | Positive N=22 No (%) | Negative N=60 No (%) | P |
| Sex | ||||
| Male | 57 (69.5) | 11 (50.0) | 46 (76.7) | |
| Female | 25 (30.5) | 11 (50.0) | 14 (23.3) | 0.02* |
| Age (years) | ||||
| Median | 61.5 | 59.5 | 62 | |
| <62 | 44 (53.7) | 13 (59.1) | 31 (51.7) | 0.55 |
| ⩾62 | 38 (46.3) | 9 (40.9) | 29 (48.3) | |
| Histology | ||||
| Adenocarcinomaa | 43 (52.4) | 12 (54.5) | 31 (51.7) | 0.59 |
| Bronchioloalveolara | 9 (11.0) | 3 (13.6) | 6 (10.0) | P (avsb) |
| Squamous cellb | 23 (28.0) | 5 (22.7) | 18 (30.0) | |
| Large cellb | 1 (1.2) | 1 (4.5) | 0 (0) | |
| Undifferentiatedb | 6 (7.3) | 1 (4.5) | 5 (8.3) | |
| Performance status | ||||
| 0 | 43 (52.4) | 12 (54.5) | 31 (51.7) | 0.7 |
| 1 | 30 (36.6) | 7 (31.8) | 23 (38.3) | P (0+1 vs 2) |
| 2 | 9 (11.0) | 3 (13.6) | 6 (10.0) | |
| Smoking status | ||||
| Never smoker | 10 (12.2) | 6 (27.3) | 4 (6.7) | 0.02* |
| Former smoker | 30 (36.6) | 6 (27.3) | 24 (40.0) | P (Never vs others) |
| Current smoker | 42 (52.2) | 10 (45.5) | 32 (53.3) | |
*
Statistically significant.
HER3 FISH− corresponds to no or low gain in copy numbers for the HER3 gene and HER3 FISH+ corresponds to high levels of gain for HER3 gene copy number (high polysomy and gene amplification).
a
Grouping for statistics.
b
Grouping for statistics.