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. 2005 Jul 5;93(2):224–232. doi: 10.1038/sj.bjc.6602685

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Copyright © 2005 Cancer Research UK

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(A) Tumour growth curves for mice bearing flank tumours derived from LLC cells from the four treatment groups. Tumour volume is expressed relative to that determined on day 0 (100%). The average maximum tumour diameter on day 12 was 16 mm. Chemotherapy groups (^* and $) P<0.05 vs control; combination chemotherapy and darbepoetin ($) P<0.05 vs chemotherapy alone (^*). Statistical analysis was performed by one-way ANOVA with LSD post hoc correction. Data are expressed as mean±s.e.m. (B) Photograph of representative tumours derived from LLC cells removed from chemotherapy and combination chemotherapy and darbepoetin-treated mice after the mice were killed on day 12 using cervical dislocation under anaesthetic. (i) Tumour from a mouse treated with chemotherapy only; (ii) tumour from a mouse treated with combination chemotherapy and darbepoetin.