Table 3. Standardised incidence ratios (SIRs) for cancer at sites other than the breast in unaffected relatives of patients with ataxia teleangectasia (AT), both sexes combined and each sex separately.
Both sexes
|
Men
|
Women
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Site of cancer | Obs | Exp | SIR | 95% CI | Obs | SIR | 95% CI | Obs | SIR | 95% CI |
All sites except breast | 191 | 155.76 | 1.2 | 1.1–1.4 | 106 | 1.2 | 1.0–1.4 | 85 | 1.3 | 1.1–1.6 |
Stomach | 17 | 12.07 | 1.4 | 0.8–2.3 | 11 | 1.5 | 0.7–2.6 | 6 | 1.3 | 0.5–2.9 |
Colon and rectum | 25 | 21.31 | 1.2 | 0.8–1.7 | 14 | 1.3 | 0.7–2.1 | 11 | 1.1 | 0.5–1.9 |
Liver and biliary passages | 8 | 2.97 | 2.7 | 1.2–5.3 | 2 | 1.4 | 0.2–5.1 | 6 | 3.9 | 1.4–8.4 |
Respiratory tract | 24 | 19.38 | 1.2 | 0.8–1.8 | 20 | 1.3 | 0.8–2.1 | 4 | 0.9 | 0.2–2.3 |
Cervix uteri | 6 | 4.51 | 1.3 | 0.5–2.9 | — | — | — | 6 | 1.3 | 0.5–2.9 |
Corpus uteri | 5 | 4.25 | 1.2 | 0.4–2.8 | — | — | — | 5 | 1.2 | 0.4–2.8 |
Ovary | 8 | 4.60 | 1.7 | 0.8–3.4 | — | — | — | 8 | 1.7 | 0.8–3.4 |
Prostate | 17 | 16.06 | 1.1 | 0.6–1.7 | 17 | 1.1 | 0.6–1.7 | — | — | — |
Urinary tract | 8 | 12.68 | 0.6 | 0.3–1.2 | 8 | 0.9 | 0.4–1.8 | 0 | 0.0 | 0.0–1.0 |
Melanoma of skin | 10 | 4.81 | 2.1 | 1.0–3.8 | 6 | 2.7 | 1.0–5.8 | 4 | 1.6 | 0.4–4.0 |
Other skin | 13 | 10.96 | 1.2 | 0.6–2.0 | 4 | 0.7 | 0.2–1.7 | 9 | 1.8 | 0.8–3.5 |
Lymphatic and haematopoietic tissues | 13 | 12.33 | 1.1 | 0.6–1.8 | 7 | 1.0 | 0.4–2.1 | 6 | 1.1 | 0.4–2.5 |
Other and unspecified | 37 | 29.83 | 1.2 | 0.9–1.7 | 17 | 1.0 | 0.6–1.7 | 20 | 1.3 | 0.8–2.1 |
Obs=observed cancers; Exp=expected cancers; CI=confidence interval.