Table 3. Types of EGFR gene mutations found in this study.

Exon	Type of sequence	Alteration	Nucleotide alteration	Amino-acid alteration	No. of cases
18		Substitution	2156G>C	G719A	1
		Substitution	2159C>T	S720F	1
19	Type 1
	1a	Deletion	2235–2249delGGAATTAAGAGAAGC	E746-A750del	14
	1b	Deletion	2236–2250delGAATTAAGAGAAGCA	E746-A750del	8
	1c	Deletion+	2235–2249delGGAATTAAGAGAAGC	E746-A750del	1
		Substitution	2251A>G	T751A
	1d	Deletion+	2235–2236delGC	E746-A750del	1
		Substitution	2242–2248delAGAGAAG	ins I and P
			2241A>C
	1e	Deletion	2235–2236delGC	E746-T751del	2
			2239–2252delTAAGAGAAGCAAC	ins I
	1f	Deletion+	2235–2236delGC	E746-T751del	1
		Substitution	2242–2251delAGAGAAGCAA	ins I and P
			2241A>C
	1g	Deletion+	2237–2254delAATTAAGAGAAGCAACAT	E746-S752del	1
		Substitution	2255C>T	ins V
	Type 2
	2a	Deletion+	2240–2248delTAAGAGAAG	L747-A750	1
		Substitution	2239T>C	insP
	2b	Deletion+	2240–2251delTAAGAGAAGCAA	L747-T751del	2
		Substitution	2239T>C	ins S
	2c	Deletion	2239–2253delTTAAGAGAAGCAACA	L747-T751del	1
	2d	Deletion	2239–2256delTTAAGAGAAGCAACATCT	L747-S752del	1
	2e	Deletion	2240–2257delTAAGAGAAGCAACATCTC	L747-P753del	1
				ins S
20		Insertion+	2308ins/dup(CCAGCGTGG)	ins779(ASV)	1
		Substitution	2310C>T, 2315C>G	P782R
		Insertion+	2311ins/dup(GCGTGGACA)	ins780(SVD)	1
		Substitution	2315C>G	P782R
21		Substitution	2573T>G	L858R	20
		Substitution	2572–2573CT>AG	L858R	1
		Substitution	2573–2574TG>GT	L858R	1