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. 2005 Jul 12;93(3):310–318. doi: 10.1038/sj.bjc.6602700

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Copyright © 2005 Cancer Research UK

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The effect of demethylation and acetylation on aRA-induced RARβ2 and CYP26A1 expression in RA-resistant cancer cells. RARβ2 and CYP26A1 expression was determined by noncompetitive RT–PCR, with expression of housekeeping gene β2M as an internal control. (A) MDA-MB-231 and SK-MES-1 cells were treated with control, aRA, and/or various concentration of aza-CdR for 3 days. (B) The cells were treated with control, aRA, and/or 0.3 μM TSA for 3 days. The last lane of each gel (+VE) contained a positive control from RA-sensitive Calu-6 cells treated with 10 μM aRA for 3 days.