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. 2005 Aug 16;93(5):557–564. doi: 10.1038/sj.bjc.6602742

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Copyright © 2005 Cancer Research UK

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Kaplan–Meyer analysis for efficiency of IFN-α/5-FU combination therapy. All 55 patients completed at least two courses of IFN-α/5-FU combination therapy. A total of 24 (43.6%) patients were assessed as objective responders; eight (14.5%) complete responders (CR), 16 (29.1%) partial responders (PR), four (7.3%) nonresponder (NC), and 27 (49.1%) showed progressive disease (PD). With respect to time-to-progression and overall survival, there was a significant difference between objective responders (CR/PR) and nonresponders (NC/PD) (P<0.0001). (A) The median progression-free survival periods of CR/PR cases (n=24) was 12.0 months and that of NC/PD cases (n=31) was 2.2 months. The 1-, 2-, and 3-year progression-free survival rates of CR/PR cases were 49.3, 20.6, and 20.6%, respectively, and those of NC/PD cases were 0, 0, and 0%, respectively. (B) The median survival period of CR/PR cases (n=24) was 24.4 months and that of NC/PD cases (n=31) was 5.4 months. The 1-, 2-, and 3-year survival rates of CR/PR cases were 82.9, 54.2, and 30.9%, respectively, and those of NC/PD cases were 13.1, 0, and 0%, respectively.