Table 2. Odds ratios (and 95% CI) of keratinocyte cancer among cases with melanoma of the head/neck, trunk, upper and lower limbs compared to controls with other solid tumours.
| Controls (N=349 923) |
Head and neck melanoma cases (N=512)
|
Trunk melanoma cases (N=1018)
|
Upper limb melanoma cases (N=749)
|
Lower limb melanoma cases (N=1569)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | % | OR (95% CI)a | Adj OR (95% CI)b | % | OR (95% CI)a | Adj OR (95% CI)b | % | OR (95% CI)a | Adj OR (95% CI)b | % | OR (95% CI)a | Adj OR (95% CI)b | |
| Any keratinocyte cancers | 3.07 | 12.50 | 4.51 (3.47–5.86) | 5.26 (4.01–6.89) | 6.39 | 2.15 (1.67–2.77) | 4.53 (3.50–5.87) | 7.34 | 2.50 (1.90–3.29) | 5.21 (3.93–6.92) | 6.15 | 2.07 (1.67–2.56) | 4.26 (3.43–5.30) |
| SCCc | 0.60 | 2.54 | 4.68 (2.69–8.13) | 5.33 (3.04–9.33) | 1.18 | 2.03 (1.15–3.59) | 4.85 (2.72–8.64) | 1.07 | 1.86 (0.92–3.74) | 4.79 (2.37–9.70) | 0.54 | 0.92 (0.46–1.84) | 2.49 (1.24–5.02) |
| BCCd | 2.55 | 10.16 | 4.40 (3.30–5.87) | 5.15 (3.84–6.92) | 5.80 | 2.35 (1.80–3.06) | 4.82 (3.68–6.32) | 5.21 | 2.13 (1.54–2.95) | 4.31 (3.09–5.99) | 4.68 | 1.89 (1.49–2.41) | 3.74 (2.92–4.78) |
a
Odds ratio and 95% confidence interval. The reference group was people with no keratinocyte cancers in each analysis.
b
Odds ratio and 95% confidence interval adjusted for exact age (in years), age squared and sex.
c
In total, 9080 people were excluded from the SCC analysis because they had no SCC diagnosis but a diagnosis of another keratinocyte cancers.
d
In total, 1975 people were excluded from the BCC analysis because they had a diagnosis of a keratinocyte cancer other than BCC.