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. 2005 Aug 23;93(5):529–537. doi: 10.1038/sj.bjc.6602740

Table 2. Dose-limiting toxicity at cycle one 38 patients.

Dose level Cohort A
Cohort B
CDDP/TMZ mg m−2 day−1 DLT/patients DLT DLT/patients DLT
80/150 1/6 Platelet transfusion >7 days 2/11 Thrombocytopenia G3 >7 days
        Platelet transfusion >7 days
         
80/200 3/11 Febrile neutropenia G4 and platelet transfusion >7 days 1/2 Neutropenia G4 and platelet transfusion >7 days
    Platelet transfusion >7 days    
    Septicaemia G3    
         
100/200 3/8 Infection during neutropenia G4 and thrombocytopenia G3 >7 days 0  
    Platelet transfusion >7 days    
    Neutropenia G4 >7 days