Table 4. MGMT activity in peripheral blood mononuclear cells.
|
ATase SA (Fm μg−1)
|
% Activity remaining following
|
||||
|---|---|---|---|---|---|
| Patient number | Day 0 | Day 1 | Day 5 | Cisplatin | Temozolomide |
| 25# | 2.8 | 7.8 | 276 | ||
| 2 | 3.1 | 3.7 | 5.5 | 119 | 177 |
| 24# | 3.9 | 11.9 | 4.1 | 309 | 107 |
| 7 | 3.9 | 5.4 | 0.85 | 140 | 22 |
| 20 | 3.9 | 12.1 | 310 | ||
| 13# | 4.3 | 5.1 | 0.4 | 120 | 9 |
| 36 | 4.9 | 3.6 | 74 | ||
| 39 | 5.9 | 6.8 | 1.1 | 115 | 19 |
| 9 | 7.1 | 9.0 | 127 | ||
| 10# | 7.5 | 3.1 | 3.1 | 41 | 41 |
| 38# | 7.8 | 3 | 1.3 | 38 | 17 |
| 6# | 8.2 | 9.0 | 0.7 | 110 | 9 |
| 15 | 8.3 | 14.3 | 9.0 | 173 | 109 |
| 4 | 10.7 | 10.9 | 2.6 | 102 | 25 |
| 17# | 11.0 | 5.4 | 4.3 | 49 | 39 |
| 12 | 12.8 | 5.5 | 6.2 | 43 | 48 |
| 21 | 12.9 | ||||
| 31# | 13.1 | 0.6 | 5 | ||
| 30# | 13.5 | 35 | 2.9 | 259 | 22 |
| 22 | 15.5 | 33.3 | 12 | 215 | 77 |
| 28 | 15.9 | 22.4 | 141 | ||
| 14 | 15.9 | 14.7 | 5.5 | 92 | 35 |
| 3 | 17.5 | 15.4 | 10.1 | 88 | 57 |
| 18 | 19.2 | 44.7 | 4.6 | 233 | 24 |
| 16# | 19.3 | 13.4 | 3.3 | 69 | 17 |
| 23 | 21.2 | 18.4 | 87 | ||
| 29 | 25.3 | 33.3 | 132 | ||
| 11# | 27.7 | 25.2 | 4.4 | 91 | 16 |
| 33 | 28.4 | 24 | 31.3 | 85 | 110 |
| 19 | 42.2 | 12.4 | 14.5 | 29 | 34 |
| 34 | 52.5 | 27.2 | 12.3 | 52 | 24 |
| Mean | 14.4 | 15.4 | 6.4 | 116 | 65 |
| Median | 12.8 | 12.4 | 4.4 | 102 | 34 |
| Range | 2.8–52.5 | 3.0–33.3 | <0.4–31.3 | 29–309% | 5–310% |
Values in bold are maximum values for sample in # marked patient.