Table 2. Biopsy results according to subsets HPV/CYTO.
| Category results | Results (n) | Satisfactory biopsies (n) | Normal biopsies | LSIL biopsies | HSIL biopsies |
|---|---|---|---|---|---|
| HPV−CYTO− | 12 508 | 502 | 491 (12 233.9) | 11 (274.1) | 0 (0) |
| HPV−CYTO+ | 191 | 124 | 75 (115.5) | 47 (72.4) | 2 (3.1) |
| HPV+CYTO+ | 302 | 240 | 77 (96.9) | 117 (147.2) | 46 (57.9) |
| HPV+CYTO− | 841 | 667 | 393 (495.5) | 240 (302.6) | 34 (42.9) |
| Total | 13 842 | 1533 | 1036 (12 941.8) | 415 (796.3) | 82 (103.9) |
Adjusted values (AHCL) for verification bias are in parentheses. They derived from the formula AHCL=FHCL+UHC *(FHCL/(FHC(normal)+FHC(LSIL)+FHC(HSIL))). L is the biopsy result. FHCL is the frequency of lesion L obtained from the study without adjustment within a given HPV/CYTO subset. UHC is the number of patients in the same subset unverified either because the biopsy was not received or the biopsy was unsatisfactory. For instance, AHPV+CYTO−(normal)=FHPV+CYTO−(normal)+UHPV+CYTO−*(FHPV+CYTO−(normal)/(FHPV+CYTO−(normal)+FHPV+CYTO−(LSIL)+FHPV+CYTO−(HSIL)))=393+(841–667) * (393/(393+240+34))=495.5 (see text in statistical method for verification bias explanation).
HSIL=high-grade squamous intraepithelial lesion; LSIL=low-grade squamous intraepithelial lesion.