Table 3. Frequencies of true positive, true negative, false positive and false negative for HPV and CYTO tests (for HSIL detection) where HPV and CYTO represent adjusted values (AHCL, see Table 2 for biopsy verification bias).
|
Test frequencies to detect CIN2/3 (HSIL) with related sensitivity and specificity adjusted with verification bias
| ||||
|---|---|---|---|---|
| Result | HPV | CYTO | Sensitivity and specificity to detect HSIL | |
| True positive | 100.8 | 61.0 | Sensitivity CYTO | 58.7% |
| True negative | 12695.9 | 13306.1 | Specificity CYTO | 96.9% |
| False positive | 1042.2 | 432.0 | Sensitivity HPV | 97.0% |
| False negative | 3.1 | 42.9 | Specificity HPV | 92.4% |
95% confidence interval: sensitivity HPV=[91.8–99.4%], sensitivity CYTO=[48.6–68.2%], specificity HPV=[91.9–92.9%] and specificity CYTO=[96.6–97.2%].