Table 5. Copy number gains and losses in paired primary breast cancers and their nodal metastases.
|
Genetic changes common to both primary and metastasis
|
Discordant genetic changes
|
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|---|---|---|---|---|---|---|
|
In primary only
|
In nodal metastasis only
|
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| Paired case # | Gains | Losses | Gains | Losses | Gains | Losses |
| 1 | 63 (33) | 9 (7) | 16 (11) | 9 (8) | 30 (25) | 12 (11) |
| 2 | 19 (13) | 10 (7) | 21 (15) | 26 (25) | 31 (30) | 15 (13) |
| 3 | 20 (11) | 1 (1) | 48 (38) | 37 (30) | 42 (35) | 22 (20) |
| 4 | 7 (5) | 9 (5) | 25 (20) | 34 (31) | 36 (33) | 24 (23) |
| 5 | 13 (7) | 0 (0) | 13 (12) | 91 (63) | 42 (29) | 4 (3) |
Number of amplified or deleted BAC clones (number of affected chromosomal bands in parentheses).