Table 3. Independent factors predictive for adverse skeletal events according to a multivariate Cox model.

Variables	Hazard ratio	95% confidence intervals	P-value
Variables not in the model
Alkaline phosphatase	1.11	0.84–1.48	0.45
Performance status	1.22	0.70–2.12	0.47
Variables in the model
Number of metastatic sites	1.16	1.07–1.25	0.000
Pain score	1.13	1.06–1.20	0.000